I once did experiment in IE6 and Firefox 2.x. The "F5" refresh would trigger a HTTP request sent to the server with an "If-Modified-Since" header, while "Ctrl+F5" would not have such a header. In my understanding, F5 will try to utilize cached content as much as possible, while "Ctrl+F5" is intended to abandon all cached content and just retrieve all content from the servers again.

But today, I noticed that in some of the latest browsers (Chrome, IE8) it doesn't work in this way anymore. Both "F5" and "Ctrl+F5" send the "If-Modified-Since" header.

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